Features of POROS CaptureSelect AAVX resin include:• One-step AAV purification from crude material with high purity and yield• High specificity and capacity, maximizing yield by significantly reducing process steps• Superior capacity maintained at high flow rates• Excellent scalability and easier handling and packing due to rigid polymeric bead• Non-animal derived

POROS CaptureSelect AAVX Affinity Resin enables a robust, fast, and platformable purification process for wide-ranging AAV serotypes with excellent purity and yield obtained in one step. This resin comes with complete technical and regulatory support.

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Main characteristics

Matrix: cross-linked poly(styrene-divinylbenzene) POROS beadsAverage particle size: 50 µmLigand: CaptureSelect AAVX affinity ligandBinding capacity: >1x1013 genome copies/mL of resinElution conditions: acidic elution with 0.1 M glycine, pH 3.0Mechanical resistance: 100 bar (1,450 psi; 10 MPa)Formulation buffer: 18% (v/v) ethanol

Free of animal componentsCaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).